Agent-based simulation of reactions in the crowded and structured intracellular environment: Influence of mobility and location of the reactants

@inproceedings{Klann2010AgentbasedSO,
  title={Agent-based simulation of reactions in the crowded and structured intracellular environment: Influence of mobility and location of the reactants},
  author={Michael Klann and Alexei Lapin and Matthias Reuss},
  booktitle={BMC Systems Biology},
  year={2010}
}
In this paper we apply a novel agent-based simulation method in order to model intracellular reactions in detail. The simulations are performed within a virtual cytoskeleton enriched with further crowding elements, which allows the analysis of molecular crowding effects on intracellular diffusion and reaction rates. The cytoskeleton network leads to a reduction in the mobility of molecules. Molecules can also unspecifically bind to membranes or the cytoskeleton affecting (i) the fraction of… CONTINUE READING
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