Agent-based computational modeling of wounded epithelial cell monolayers

  title={Agent-based computational modeling of wounded epithelial cell monolayers},
  author={D. C. Walker and G. Hill and S. Wood and R. H. Smallwood and Jennifer Southgate},
  journal={IEEE Transactions on NanoBioscience},
Computational modeling of biological systems, or in silico biology, is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed and used to predict the healing characteristics of scratch wounds made to urothelial cell cultures maintained in low- and physiological [Ca/sup 2+/] environments. Both computational models and in vitro experiments demonstrated that in low… CONTINUE READING
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