Ageing of Neurospora crassa. VI. Cytochemical and cytological correlates of senescence in three model systems

  title={Ageing of Neurospora crassa. VI. Cytochemical and cytological correlates of senescence in three model systems},
  author={Rajendra S. Rana and Kenneth D. Munkres},
  journal={Mechanisms of Ageing and Development},

Inositol-Limited Growth, Repair, and Translocation in an Inositol-Requiring Mutant of Neurospora crassa

These results are consistent with cell lysis occurring in the mutant grown on limiting inositol because of a structurally weakened cell wall and membrane deterioration.

Unstable mitochondrial DNA in natural-death nuclear mutants of Neurospora crassa

Traits of the natural-death mutant of Neurospora crassa indicate that the nd+ allele codes for a function that is essential for stable maintenance of the mitochondrial chromosome, possibly a protein involved in replication, repair, or recombination.

Hyperactive recombination in the mitochondrial DNA of the natural death nuclear mutant of Neurospora crassa

The implication of these results is that the nd allele hyperactivates a general system for homologous recombination in the mitochondria of N. crassa.

Phase Resetting of the Neurospora crassa Circadian Oscillator: Effects of Inositol Depletion on Sensitivity to Light

An indirect role for inositol metabolites in the light input pathway—one that is not likely to involve direct participation of an inositl phospholipid signal transduction mechanism is indicated.



Inositol Deficiency Resulting in Death: An Explanation of Its Occurrence in Neurospora crassa

In mycelia of the mutant requiring inositol, grown in a suboptimum amount of exogenous inositols, the strlctural initegrity of the protease particles is lost, and the bulk of intracellular protease activity is recovered in the soluble fraction of the cell.

Respiration of Wild Type and Extrachromosomal Mutants of Neurospora crassa

A dynamic model of regulation of mitochondrial biogenesis in the coordination of the synthesis of mitochondrial proteins encoded by nuclear and mitochondrial genomes is discussed.

Multiple Alterations in Metabolite Uptake in a Mutant of Neurospora crassa

A temperature-conditional lethal mutant of Neurospora crassa, un-t (55701), was resistant to neutral amino acid analogues by virtue of a decreased ability to transport these analogues and their natural congeners across the cell membrane and the possibility that the mutant has a generalized membrane defect is discussed.

Increase in microviscosity with ageing in protoplast plasmalemma of rose petals

A gradual increase in microviscosity of protoplast plasmalemma from petals of ageing rose flowers is reported, indicating importance in regulating various physiological activities, as in lymphocytes and erythrocytes.

Glucose Utilization and Ethanolic Fermentation by Wild Type and Extrachromosomal Mutants of Neurospora crassa

It is suggested that the Pasteur effect, the inhibition of fermentation by respiration, may be operative in N. crassa and factors such as nitrogen source and concentration and oxygen tension, which may serve primarily to regulate the amount and form of respiration would, therefore, indirectly regulate fermentation.