Ageing is associated with a prolonged fever response in human endotoxemia.

@article{Krabbe2001AgeingIA,
  title={Ageing is associated with a prolonged fever response in human endotoxemia.},
  author={Karen Su{\'a}rez Krabbe and Helle Bruunsgaard and Christina M{\o}rk Hansen and M. Brian Pedersen and Lise Fonsmark and Jesper Qvist and Peter Lund Madsen and Gitte Kronborg and Henrik Orbaek Andersen and Peter Skinh{\o}j and Bente Klarlund Pedersen},
  journal={Clinical and diagnostic laboratory immunology},
  year={2001},
  volume={8 2},
  pages={
          333-8
        }
}
The purpose of this study was to investigate whether an age-associated impaired acute-phase response exists. Nine healthy elderly volunteers (median, 66 years; range, 61 to 69 years) and eight young controls (median, 24 years; range, 20 to 27 years) were given an intravenous bolus of endotoxin (2 ng/kg). The rectal temperature was monitored continuously, and blood samples for cytokine measurements were obtained before endotoxin administration as well as 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h… CONTINUE READING

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