Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.

@article{Delp2008AgeingDE,
  title={Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.},
  author={Michael Delp and Bradley J Behnke and Scott A Spier and Guoyao Wu and Judy M Muller-Delp},
  journal={The Journal of physiology},
  year={2008},
  volume={586 4},
  pages={1161-8}
}
Ageing reduces endothelium-dependent vasodilatation through an endothelial nitric oxide synthase (NOS) signalling pathway. The purpose of this study was to determine whether arginase activity diminishes endothelium-dependent vasodilatation in skeletal muscle arterioles from old rats, and whether NOS substrate (L-arginine) and cofactor (tetrahydrobiopterin; BH(4)) concentrations are reduced. First-order arterioles were isolated from the soleus muscle of young (6 months old) and old (24 months… CONTINUE READING

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