Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey.

@article{Taylor1992AgeingCG,
  title={Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey.},
  author={Lydia Taylor and Christopher K. Daniels and Douglas L. Schmucker},
  journal={Immunology},
  year={1992},
  volume={75 4},
  pages={614-8}
}
Most research on the effects of ageing on gut mucosal immunity has been performed using rodents. However, there are inherent difficulties in the extrapolation of rodent data to humans. This study was initiated to define age-related changes in the gastrointestinal (GI) mucosal immune response in non-human primates. Antibody responses were measured in young and old rhesus monkeys (Macaca mulatta) immunized intraduodenally with cholera toxin (Ctx)/cholera toxoid (Ctd). Antigen-specific… CONTINUE READING
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