Ageing and the brain.

  title={Ageing and the brain.},
  author={Margaret M. Esiri},
  journal={The Journal of pathology},
  volume={211 2},
In this review, the evidence for changes in the human brain with ageing at both the macroscopic and microscopic levels is summarized. Loss of neurons is now recognized to be more modest than initial studies suggested and only affects some neuron populations. Accompanying loss of neurons is some reduction in the size of remaining neurons. This reflects a reduced size of dendritic and axonal arborizations. Some of the likely causes of these changes, including free radical damage resulting from a… CONTINUE READING

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