Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections

Abstract

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.

DOI: 10.1038/nri2318
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@article{Nikolichugich2008AgeingAL, title={Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections}, author={Janko Nikolich-Žugich}, journal={Nature Reviews Immunology}, year={2008}, volume={8}, pages={512-522} }