Ageing and brain white matter structure in 3,513 UK Biobank participants

@inproceedings{Cox2016AgeingAB,
  title={Ageing and brain white matter structure in 3,513 UK Biobank participants},
  author={Simon R. Cox and S. J. Ritchie and Elliot Tucker-Drob and David C M Liewald and Saskia P Hagenaars and Gareth E. Davies and Joanna M. Wardlaw and Catharine R Gale and Mark E. Bastin and Ian J. Deary},
  booktitle={Nature communications},
  year={2016}
}
Quantifying the microstructural properties of the human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely studied indices from neurite orientation dispersion and density imaging, we document large age associations with white matter microstructure. Mean… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2018
VIEW 8 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants

  • Cerebral cortex
  • 2018
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Sex differences in the adult human brain

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 81 REFERENCES

Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017

Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer’s disease

N Colgan
  • NeuroImage 125,
  • 2016