Ageing, oxidative stress and cancer: paradigms in parallax

  title={Ageing, oxidative stress and cancer: paradigms in parallax},
  author={C. Benz and C. Yau},
  journal={Nature Reviews Cancer},
  • C. Benz, C. Yau
  • Published 2008
  • Biology, Medicine
  • Nature Reviews Cancer
  • Two paradigms central to geroscience research are that aging is associated with increased oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers arising with ageing will show evidence of increased oxidative stress. Recent studies of gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer… CONTINUE READING

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    Oxidants, oxidative stress and the biology of ageing
    • 7,420
    • PDF
    Oxidative stress and cancer: have we moved forward?
    • 1,103
    • PDF
    Mitochondria, oxygen free radicals, disease and ageing.
    • 973
    • PDF
    The ageing mitochondrial genome
    • 80
    • PDF
    Trends in oxidative aging theories.
    • 953
    • PDF
    Puzzles, promises and a cure for ageing
    • 330
    • PDF
    Mitotic misregulation and human aging.
    • 555
    • PDF