Ageing, neuroinflammation and neurodegeneration.

@article{Ward2015AgeingNA,
  title={Ageing, neuroinflammation and neurodegeneration.},
  author={R. Ward and D. Dexter and R. Crichton},
  journal={Frontiers in bioscience},
  year={2015},
  volume={7},
  pages={
          189-204
        }
}
During ageing, different iron complexes accumulate in specific brain regions which are associated with motor and cognitive dysfunction. In neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in local iron homoeostasis result in altered cellular iron distribution and accumulation, ultimately inducing neurotoxicity. The use of iron chelators which are able to penetrate the blood brain barrier and reduce excessive iron accumulation in specific brain regions… Expand
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