• DOI:10.2741/S433
Corpus ID: 22511026

Ageing, neuroinflammation and neurodegeneration.

@article{Ward2015AgeingNA,
  title={Ageing, neuroinflammation and neurodegeneration.},
  author={R. Ward and D. Dexter and R. Crichton},
  journal={Frontiers in bioscience},
  year={2015},
  volume={7},
  pages={
          189-204
        }
}

• R. Ward, D. Dexter, R. Crichton
• Published 2015
• Medicine
• Frontiers in bioscience

During ageing, different iron complexes accumulate in specific brain regions which are associated with motor and cognitive dysfunction. In neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in local iron homoeostasis result in altered cellular iron distribution and accumulation, ultimately inducing neurotoxicity. The use of iron chelators which are able to penetrate the blood brain barrier and reduce excessive iron accumulation in specific brain regions… Expand

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