Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.

@article{Davani2004AgedTM,
  title={Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.},
  author={Behrous Davani and Neil Portwood and Galina Bryzgalova and Martina Kvist Reimer and Thomas Heiden and C. G. Ostenson and Sam Okret and Bo Ahr{\'e}n and Suad Efend{\'i}c and Akhtar Khan},
  journal={Diabetes},
  year={2004},
  volume={53 Suppl 1},
  pages={S51-9}
}
Glucocorticoids are diabetogenic hormones because they decrease glucose uptake, increase hepatic glucose production, and inhibit insulin release. To study the long-term effects of increased glucocorticoid sensitivity in beta-cells, we studied transgenic mice overexpressing the rat glucocorticoid receptor targeted to the beta-cells using the rat insulin I promoter. Here we report that these mice developed hyperglycemia both in the fed and the overnight-fasted states at 12-15 months of age… CONTINUE READING
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Involvement of adrenergic receptors in the regulation of insulin release in transgenic mice with overexpressed -cell glucocorticoid receptor (Abstract)

  • ZC Ling, B Davani, CG Östenson, S Okret, S Efendic, A Khan
  • Diabetologia 41 (Suppl. 1):A-153,
  • 1998

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