Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.

@article{Fulton2013AgedME,
  title={Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.},
  author={Ross B. Fulton and Kayla A. Weiss and Lecia L. Pewe and John T Harty and Steven M. Varga},
  journal={Journal of virology},
  year={2013},
  volume={87 23},
  pages={
          12694-700
        }
}
Respiratory virus infections in the elderly result in increased rates of hospitalization and death. Respiratory syncytial virus (RSV) is a leading cause of severe virus-induced respiratory disease in individuals over the age of 65. CD8 T cells play a critical role in mediating RSV clearance. While it is clear that T cell immunity declines with age, it is not clear to what extent the CD8 T cell response to RSV is altered. Using aged BALB/c mice, we demonstrated that RSV-specific CD8 T cell… CONTINUE READING

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