Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration.

@article{Kang2012AgedHC,
  title={Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration.},
  author={Kai Kang and Lu Sun and Yun Xiao and Shu-hong Li and Jun Wu and Jian Guo and S. Jiang and Lei Yang and Terrence M. Yau and Richard D. Weisel and Milica Radisic and R. K.-Y. Li},
  journal={Journal of the American College of Cardiology},
  year={2012},
  volume={60 21},
  pages={2237-49}
}
OBJECTIVES This study investigated whether cytokine enhancement of a biodegradable patch could restore cardiac function after surgical ventricular restoration (SVR) even when seeded with cells from old donors. BACKGROUND SVR can partially restore heart size and improve function late after an extensive anterior myocardial infarction. However, 2 limitations include the stiff synthetic patch used and the limited healing of the infarct scar in aged patients. METHODS We covalently immobilized 2… CONTINUE READING
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