Aged Mice Have Enhanced Endocortical Response and Normal Periosteal Response Compared With Young-Adult Mice Following 1 Week of Axial Tibial Compression

@inproceedings{Brodt2010AgedMH,
  title={Aged Mice Have Enhanced Endocortical Response and Normal Periosteal Response Compared With Young-Adult Mice Following 1 Week of Axial Tibial Compression},
  author={Michael D. Brodt and M. J. Vaz-da Silva},
  booktitle={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010}
}
With aging, the skeleton may lose its ability to respond to positive mechanical stimuli. We hypothesized that aged mice are less responsive to loading than young-adult mice. We subjected aged (22 months) and young-adult (7 months) BALB/c male mice to daily bouts of axial tibial compression for 1 week and evaluated cortical and trabecular responses using micro-computed tomography (µCT) and dynamic histomorphometry. The right legs of 95 mice were loaded for 60 rest-inserted cycles per day to 8… CONTINUE READING
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