Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze.

@article{Prut2007AgedAM,
  title={Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze.},
  author={Laetitia Prut and Doroth{\'e}e Abramowski and Thomas Krucker and Coree L Levy and Amanda J Roberts and Matthias Staufenbiel and Christoph Wiessner},
  journal={Behavioural brain research},
  year={2007},
  volume={179 1},
  pages={107-10}
}
Spatial learning and memory deficits in the APP23 transgenic mice have mainly been studied using the Morris water maze (MWM). However learning in the MWM relies on swimming abilities and may be confounded by the stressful nature of this test. We have therefore assessed spatial learning and memory in 12-month-old APP23 using a dry-land maze test developed by Barnes. Mice were given daily learning trials for a total of 41 successive days. After a 12-day interval the mice were re-tested for 4… CONTINUE READING
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