Age to survive: DNA damage and aging.

@article{Schumacher2008AgeTS,
  title={Age to survive: DNA damage and aging.},
  author={Bj{\"o}rn Schumacher and George A Garinis and Jan H. J. Hoeijmakers},
  journal={Trends in genetics : TIG},
  year={2008},
  volume={24 2},
  pages={77-85}
}
Aging represents the progressive functional decline and increased mortality risk common to nearly all metazoans. Recent findings experimentally link DNA damage and organismal aging: longevity-regulating genetic pathways respond to the accumulation of DNA damage and other stress conditions and conversely influence the rate of damage accumulation and its impact for cancer and aging. This novel insight has emerged from studies on human progeroid diseases and mouse models that have deficient DNA… CONTINUE READING

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predisposition and segmental progeria

  • Jaspers, N.G
  • Cancer Cell 10,
  • 2007

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

  • Niedernhofer, L.J
  • Nature 444,
  • 2006

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