Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.

Abstract

The expansion of simple sequence CAG•CTG repeats is associated with a number of inherited disorders including Huntington disease (HD), myotonic dystrophy type 1 and several of the spinocerebellar ataxias. Inherited disease-associated alleles usually exceed 40 repeats and may be in excess of 1,000 repeats in some disorders. Inherited allele length is… (More)
DOI: 10.1016/j.nbd.2015.01.004

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Cite this paper

@article{Larson2015AgeTA, title={Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.}, author={Eloise Larson and Ian S Fyfe and A. Jennifer Morton and Darren G. Monckton}, journal={Neurobiology of disease}, year={2015}, volume={76}, pages={98-111} }