Age-stratified outcome of a genotype-guided dosing algorithm for acenocoumarol and phenprocoumon.


Essentials The EU-PACT trial was used to investigate age on the interaction between coumarins and genotype. The results support the use of genotype-guided dosing for phenprocoumon in patients < 75 years. For patients ≥ 75 years the phenprocoumon algorithm should be revised and further tested. No influence of comorbidities and co-current drug use was found… (More)
DOI: 10.1111/jth.13601


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