Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.

Abstract

OBJECTIVE To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease (PD). METHODS PD patients (n = 78) and healthy control subjects (n = 35) underwent longitudinal positron emission tomography assessments using 3 presynaptic dopamine markers: (1) [¹¹C](±)dihydrotetrabenazine (DTBZ), to estimate the density of… (More)
DOI: 10.1002/ana.22284

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