Age-specific effects of early MK-801 treatment on working memory in female rats.

@article{Su2011AgespecificEO,
  title={Age-specific effects of early MK-801 treatment on working memory in female rats.},
  author={Yunai Su and Xiao-Dong Wang and J Li and Chun-Mei Guo and Yu Feng and Yang Yang and Run-Hu Huang and Tian-Mei Si},
  journal={Neuroreport},
  year={2011},
  volume={22 8},
  pages={402-6}
}
The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory… CONTINUE READING