Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.


PURPOSE With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mg/kg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder. METHODS Experiments were performed in 12-, 18-, and 60-day-old (adult) rats. The effects of… (More)