Age-related shift in brain region activity during successful memory performance

@article{Hazlett1998AgerelatedSI,
  title={Age-related shift in brain region activity during successful memory performance},
  author={Erin A. Hazlett and Monte S. Buchsbaum and Richard C. Mohs and J Spiegel–Cohen and Philip D. Harvey},
  journal={Neurobiology of Aging},
  year={1998},
  volume={19},
  pages={437-445}
}
Coregistered positron emission tomography (PET)/magnetic resonance imaging (MRI) was used to characterize brain function in 70 volunteers, aged 20-87 years, during a verbal memory task. Frontal activity showed an age-related decline that remained significant after statistical control for sulcal atrophy. Analyses of young and old subgroups matched for memory scores revealed that young good performers activated frontal regions, whereas old good performers relied on occipital regions. Although… CONTINUE READING
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