Age-related sensitivity and pathological differences in infections by 2009 pandemic influenza A (H1N1) virus

@inproceedings{Sun2010AgerelatedSA,
  title={Age-related sensitivity and pathological differences in infections by 2009 pandemic influenza A (H1N1) virus},
  author={Shihui Sun and Guang-Yu Zhao and Wenjun Xiao and Jingya Hu and Yan Guo and Hong Yu and Xiaohong Wu and Yadi Tan and Yusen Zhou},
  booktitle={Virology Journal},
  year={2010}
}
BackgroundThe highly pandemic 2009 influenza A H1N1 virus infection showed distinguished skewed age distribution with majority of infection and death in children and young adults. Although previous exposure to related antigen has been proposed as an explanation, the mechanism of age protection is still unknown.MethodsIn this study, murine model of different ages were inoculated intranasally with H1N1 (A/Beijing/501/09) virus and the susceptibility and pathological response to 2009 H1N1… CONTINUE READING

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