Age-related reference ranges: significance tests for models and confidence intervals for centiles.

@article{Wade1994AgerelatedRR,
  title={Age-related reference ranges: significance tests for models and confidence intervals for centiles.},
  author={Angela Mills Wade and Anthony E. Ades},
  journal={Statistics in medicine},
  year={1994},
  volume={13 22},
  pages={2359-67}
}
A method of fitting age-related reference ranges using maximized likelihood is presented. The method is illustrated using CD4 counts of uninfected children born to HIV-1 infected women. The likelihood incorporates exponential functions to describe the Box-Cox transformation parameter that induces Normality and the mean and standard deviation of the transformed data, at all ages in the range. This guarantees that the centiles are asymptotic to notional adult values and avoids edge effects… CONTINUE READING

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