Age-related reduction of NO availability and oxidative stress in humans.

  title={Age-related reduction of NO availability and oxidative stress in humans.},
  author={Stefano Taddei and Agostino Virdis and Lorenzo Ghiadoni and Guido Salvetti and Giampaolo Bernini and Armando Magagna and Angelo Salvetti},
  volume={38 2},
Age-related endothelial dysfunction could be caused by an alteration in the L-arginine-NO system and the production of oxidative stress in both normotensive and hypertensive individuals. In 47 normotensive subjects and 49 patients with essential hypertension, we evaluated forearm blood flow (by strain-gauge plethysmography) modifications induced by intrabrachial sodium nitroprusside (1, 2, and 4 microg/100 mL per minute) and acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 microg/100 mL per minute… CONTINUE READING
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Role of products of univalent reduction of oxygen in hypertensive vascular injury

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