Age-related reduction in microcolumnar structure correlates with cognitive decline in ventral but not dorsal area 46 of the rhesus monkey.

@article{Cruz2009AgerelatedRI,
  title={Age-related reduction in microcolumnar structure correlates with cognitive decline in ventral but not dorsal area 46 of the rhesus monkey.},
  author={Luis Felipe S. Cruz and Dana L. Roe and Brigita Urbanc and Alistair Inglis and H. Eugene Stanley and Douglas L. Rosene},
  journal={Neuroscience},
  year={2009},
  volume={158 4},
  pages={1509-20}
}
The age-related decline in cognitive function that is observed in normal aging monkeys and humans occurs without significant loss of cortical neurons. This suggests that cognitive impairment results from subtle, sub-lethal changes in the cortex. Recently, changes in the structural coherence in mini- or microcolumns without loss of neurons have been linked to loss of function. Here we use a density map method to quantify microcolumnar structure in both banks of the sulcus principalis (prefrontal… CONTINUE READING