Age-related permeability changes in rabbit corneas.

@article{Ke1999AgerelatedPC,
  title={Age-related permeability changes in rabbit corneas.},
  author={T L Ke and Abbot F. Clark and Robert W. Gracy},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  year={1999},
  volume={15 6},
  pages={
          513-23
        }
}
The present study was designed to determine whether the corneal penetration of test compounds is altered in aging. Experiments were carried out by means of passive transport under steady-state conditions using in vitro diffusion cells. Permeabilities of a variety of compounds with different physicochemical properties were measured in young (six weeks) and old (three to four years) intact and denuded (wounded) rabbit corneas. There was a marked difference in penetration of compounds between… CONTINUE READING

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