Age-related myelin degradation burdens the clearance function of microglia during aging.

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

DOI: 10.1038/nn.4325

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@article{Safaiyan2016AgerelatedMD, title={Age-related myelin degradation burdens the clearance function of microglia during aging.}, author={Shima Safaiyan and Nirmal Kannaiyan and Nicolas Snaidero and Simone Brioschi and Knut Biber and Simon Yona and Aimee L Edinger and Steffen Jung and Moritz J Rossner and Mikael Simons}, journal={Nature neuroscience}, year={2016}, volume={19 8}, pages={995-8} }