Age-related molecular reorganization at the node of Ranvier.

  title={Age-related molecular reorganization at the node of Ranvier.},
  author={Jason D Hinman and Alan Peters and Howard J Cabral and Douglas L. Rosene and William Hollander and Matthew N Rasband and Carmela R. Abraham},
  journal={The Journal of comparative neurology},
  volume={495 4},
In myelinated axons, action potential conduction is dependent on the discrete clustering of ion channels at specialized regions of the axon, termed nodes of Ranvier. This organization is controlled, at least in part, by the adherence of myelin sheaths to the axolemma in the adjacent region of the paranode. Age-related disruption in the integrity of internodal myelin sheaths is well described and includes splitting of myelin sheaths, redundant myelin, and fluctuations in biochemical constituents… CONTINUE READING
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