Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences.

@article{Atkinson2008AgerelatedME,
  title={Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences.},
  author={Jeffrey Atkinson},
  journal={Journal of applied physiology},
  year={2008},
  volume={105 5},
  pages={1643-51}
}
With age, the calcium content of the arterial wall increases. Calcification occurs at two main levels: intimal plaques and the medial elastic fiber network. The latter has been referred to as medial elastocalcinosis and is the subject of this review. The mechanisms involved in elastocalcinosis are complex and involve polar, apolar, and active processes. Vascular calcification may be species specific to humans. As laboratory animals, such as the rat, grow old, they suffer from only very mild… CONTINUE READING
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  • V Marque, P Kieffer, B Gayraud, I Lartaud-Idjouadiène, F Ramirez, J. Atkinson
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