Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q.

@article{Klein1998AgerelatedMD,
  title={Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q.},
  author={Michael L. Klein and Dennis W. Schultz and Albert A. Edwards and Tara Cox Matise and Kristal Rust and C B Berselli and Karmen M Trzupek and Richard G. Weleber and J{\"u}rg Ott and Mary K. Wirtz and Ted S. Acott},
  journal={Archives of ophthalmology},
  year={1998},
  volume={116 8},
  pages={1082-8}
}
OBJECTIVES To identify the chromosomal location of a disease-causing gene and to describe the clinical characteristics of a large family with age-related macular degeneration (ARMD). METHODS An ARMD pedigree was identified, and the disease state of family members was documented by stereoscopic fundus photography and was classified using a modified version of the Wisconsin Age-Related Maculopathy Grading System. A genome-wide screen at approximately 6-centimorgan spacing using a DNA-pooling… CONTINUE READING