Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

@article{Fritsche2008AgerelatedMD,
  title={Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA},
  author={Lars G. Fritsche and Thomas Loenhardt and Andreas Janssen and Sheila A Fisher and Andrea Rivera and Claudia N. Keilhauer and Bernhard H F Weber},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={892-896}
}
Age-related macular degeneration (AMD) is a prevalent multifactorial disorder of the central retina. Genetic variants at two chromosomal loci, 1q31 and 10q26, confer major disease risks, together accounting for more than 50% of AMD pathology. Signals at 10q26 center over two nearby genes, ARMS2 (age-related maculopathy susceptibility 2, also known as LOC387715) and HTRA1 (high-temperature requirement factor A1), suggesting two equally probable candidates. Here we show that a deletion-insertion… Expand
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