Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina

@inproceedings{Kanda2010AgerelatedMD,
  title={Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina},
  author={Atsuhiro Kanda and Dwight E. Stambolian and Wei Chen and Christine A. Curcio and Gonçalo R. Abecasis and Anand Swaroop},
  booktitle={Molecular vision},
  year={2010}
}
PURPOSE Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD). In different reports, the del443ins54 and rs11200638 variants are suggested to affect ARMS2 mRNA stability and/or HTRA1 mRNA expression, respectively. The goal of this study is… CONTINUE READING