Age-related macular degeneration and the complement system.

  title={Age-related macular degeneration and the complement system.},
  author={Sam Khandhadia and Valentina Cipriani and John R. W. Yates and Andrew J. Lotery},
  volume={217 2},
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. It is a complex multifactorial disease, and despite new advances in treatment, many patients still succumb to visual impairment. The complement pathway has been implicated in the pathogenesis of many diseases, and recently variants in several genes encoding complement pathway proteins have been associated with AMD. Complement proteins have been found in histological specimens of eyes with AMD… CONTINUE READING

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