Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia.

@article{Samengo2012AgerelatedLO,
  title={Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia.},
  author={Giuseppina Samengo and Anna L Avik and Brian Fedor and Daniel M Whittaker and Kyu H Myung and Michelle Wehling-Henricks and James G. Tidball},
  journal={Aging cell},
  year={2012},
  volume={11 6},
  pages={1036-45}
}
Sarcopenia, the age-related loss of muscle mass, is a highly-debilitating consequence of aging. In this investigation, we show sarcopenia is greatly reduced by muscle-specific overexpression of calpastatin, the endogenous inhibitor of calcium-dependent proteases (calpains). Further, we show that calpain cleavage of specific structural and regulatory proteins in myofibrils is prevented by covalent modification of calpain by nitric oxide (NO) through S-nitrosylation. We find that calpain in adult… CONTINUE READING
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The Authors Aging Cell a 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland

  • G. Samengo
  • 2012

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