Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin.

@article{Hamrick2006AgerelatedLO,
  title={Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin.},
  author={Mark W Hamrick and K X Ding and Catherine Pennington and Yuh J. Chao and Yii-Der Wu and Boyd Howard and David M Immel and Cesario V. Borlongan and Paul McNeil and Wendy B. Bollag and Walton W. Curl and Jack Yu and Carlos M. Isales},
  journal={Bone},
  year={2006},
  volume={39 4},
  pages={845-53}
}
The mechanisms underlying age-related loss of muscle and bone tissue are poorly understood but are thought to involve changes in sex hormone status, physical activity, and circulating levels of inflammatory cytokines. This study attempts to develop an animal model useful for evaluating these mechanisms in vivo. Male C57BL/6 mice were included for study at 3, 6, 12, 18, 24, and 29 months of age. Endocortical mineralizing surface, serum leptin, body weight, and percentage of body fat all… CONTINUE READING