Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.

Abstract

BACKGROUND The pathogenesis of gut inflammation, bacterial dysbiosis and increased rates of malignancy in CF is unclear. Fecal M2-pyruvate kinase (M2-PK) is a biomarker indicative of cellular proliferation that may be raised in intestinal malignancy and inflammation. Biomarkers, including M2-PK, may be useful in assessing effects of novel therapies on the gastrointestinal tract. METHODS M2-PK was measured in stools collected from patients with CF and HC (0-10years). Linear mixed model analysis was used. RESULTS M2-PK levels did not significantly change in children with CF (36 patients, 77 samples) (P=0.998) or HC (45 patients, 45 samples) (P=0.21), over the age range 0-10years. Patients with CF had elevated M2-PK compared to HC (median [IQR; range]: 10.7 [5.7-28.6; 1.0-239.1] (n=77) vs. 1.0 [1.0-1.0; 1.0-50.0] (n=45) U/mL, respectively; P=0.001). CONCLUSIONS Fecal M2-PK was elevated in children with CF compared with HC during infancy and throughout childhood suggesting abnormalities in the CF gut exist in early life.

DOI: 10.1016/j.jcf.2017.07.011

Cite this paper

@article{Garg2017AgerelatedLO, title={Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.}, author={Millie Garg and Steven T Leach and Tamara Pang and Bronwen Needham and Michael J Coffey and Tamarah Katz and Roxanne E. Strachan and John A Widger and Penelope Field and Yvonne C. Belessis and Sandra Ya-Chu Chuang and Andrew S Day and Adam Jaffe and Chee Yee Ooi}, journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society}, year={2017} }