Age-related levels of GABA/benzodiazepine binding sites in cerebrum of F-344 rats: Effects of exercise

  title={Age-related levels of GABA/benzodiazepine binding sites in cerebrum of F-344 rats: Effects of exercise},
  author={M. H. Tehrani and C. Tate and M. I. Al-Dahan},
  journal={Neurobiology of Aging},
  • M. H. Tehrani, C. Tate, M. I. Al-Dahan
  • Published 1995
  • Chemistry, Medicine
  • Neurobiology of Aging
  • We examined gamma-aminobutyric acid (GABA), benzodiazepine and convulsant sites of postsynaptic GABA/benzodiazepine receptors (GBZR) in cerebral membranes of inbred Fischer 344 male rats as a function of age. In aged rats (23 to 24 months), the benzodiazepine binding site as determined by [3H]flunitrazepam was 47% and 43% lower than corresponding values in young adult (3 to 4 months) and mature (10 to 12 months) rats, respectively. The decrease was due to the loss of binding density rather than… CONTINUE READING
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