Age-related increase of stem marker expression influences vascular smooth muscle cell properties.

@article{Ferlosio2012AgerelatedIO,
  title={Age-related increase of stem marker expression influences vascular smooth muscle cell properties.},
  author={Amedeo Ferlosio and Gaetano Arcuri and Elena Doldo and Maria Giovanna Scioli and S De Falco and Luigi Giusto Spagnoli and Augusto Orlandi},
  journal={Atherosclerosis},
  year={2012},
  volume={224 1},
  pages={
          51-7
        }
}
OBJECTIVE Aging represents a major risk factor for vascular disease development. With aging, changes of the biological properties of vascular smooth muscle cells (SMCs) are observed. Stem marker expression characterizes SMCs during developmental growth and atherosclerosis, but the contribution of SMCs with stem features to the age-related arterial remodeling remains largely unknown. METHODS AND RESULTS Immunostaining revealed rare vascular growth factor receptor-1(+) (flt-1(+)) and c-kit… CONTINUE READING
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