Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changes.

@article{Kepplinger2005AgerelatedIO,
  title={Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changes.},
  author={Berthold Kepplinger and Halina Baran and Astrid Kainz and Heber Ferraz-Leite and Jea Newcombe and Pavol Kalina},
  journal={Neuro-Signals},
  year={2005},
  volume={14 3},
  pages={126-35}
}
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA is synthesised from L-kynurenine by kynurenine aminotransferases (KAT) I and II. A host of immune mediators influence tryptophan degradation. In the present study, the levels of KYNA in cerebrospinal fluid (CSF) and serum in a group of human… CONTINUE READING

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