Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger.

@article{Inada1996AgerelatedII,
  title={Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger.},
  author={Ken ichi Inada and Isao Yokoi and Hideaki Kabuto and Hirofumi Habu and Akihisa Mori and Norio Ogawa},
  journal={Mechanisms of ageing and development},
  year={1996},
  volume={89 2},
  pages={95-102}
}
The levels of nitric oxide (NO) and NO synthase (NOS) activities were compared in the brains of young adult (3 months old), aged (11 months old) and TJ-960 administered (11 months old) senescence accelerated mice (SAM), of which the SAMP8 substrain is inferior in acquisition of learning due to the abnormality of glutamatergic neurotransmission in the cerebral cortex. TJ-960, which is based on the Kampo (Japanese traditional herbal medicine) prescription Sho-saiko-to-go-keishi-ka-shakuyaku-to… CONTINUE READING