Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training.

@article{Consitt2016AgerelatedII,
  title={Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training.},
  author={Leslie A Consitt and Gunjan Saxena and Alicson Saneda and Joseph A. Houmard},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2016},
  volume={311 1},
  pages={E145-56}
}
The purpose of this study was to determine whether plasma lactate and skeletal muscle glucose regulatory pathways, specifically PDH dephosphorylation, are impaired during hyperinsulinemic conditions in middle- to older-aged individuals and determine whether exercise training could improve key variables responsible for skeletal muscle PDH regulation. Eighteen young (19-29 yr; n = 9 males and 9 females) and 20 middle- to older-aged (57-82 yr; n = 10 males and 10 females) individuals underwent a 2… CONTINUE READING
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