Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome.

@article{Bianchi2014AgerelatedIO,
  title={Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome.},
  author={Patrizia Grace Bianchi and Simone Bettini and Sandra Guidi and Elisabetta Ciani and Stefania Trazzi and Fiorenza Stagni and Elena Ragazzi and Valeria Franceschini and Renata Bartesaghi},
  journal={Experimental neurology},
  year={2014},
  volume={251},
  pages={1-11}
}
Down syndrome (DS) is a genetic condition caused by triplication of chromosome 21. Widespread neurogenesis reduction during brain development underlies the numerous neurological defects of DS. These defects start to manifest themselves at birth and worsen with age. However, unlike other brain functions, smell is impaired only at advanced life stages, suggesting preservation of olfactory bulb neurogenesis up to adulthood. To clarify this issue, in the current study we examined olfactory bulb (OB… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…