Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study.

@article{Sandri2012AgerelatedEO,
  title={Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study.},
  author={Marcus Sandri and Irina Kozarez and Volker Adams and Norman Mangner and Robert Hoellriegel and Sandra Erbs and Axel Linke and Sven Moebius-Winkler and Joachim Thiery and J{\"u}rgen Kratzsch Kratzsch and Daniel Teupser and Meinhard Mende and Rainer Hambrecht and Gerhard A. Schuler and Stephan Gielen},
  journal={European heart journal},
  year={2012},
  volume={33 14},
  pages={1758-68}
}
AIMS Diastolic dysfunction (DD) was identified as a predictor of adverse prognosis in heart failure with reduced ejection fraction (HFREF). It is, however, unknown if DD is improved by exercise training, which is known to induce reverse remodelling, and if the training effect is attenuated in elderly HFREF patients. We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years… CONTINUE READING