Age-related effects of chlorpyrifos on acetylcholine release in rat brain.

@article{Won2001AgerelatedEO,
  title={Age-related effects of chlorpyrifos on acetylcholine release in rat brain.},
  author={Yen Kim Won and Jing ai Liu and Kenneth Olivier and Quanmei Zheng and Carey Pope},
  journal={Neurotoxicology},
  year={2001},
  volume={22 1},
  pages={39-48}
}
Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE). Young animals are markedly more sensitive than adults to the acute toxicity of CPF. We evaluated acetylcholine (ACh) release and its muscarinic receptor-mediated regulation (i.e. muscarinic autoreceptor function, MAF) during maturation as a possible contributing factor to age-related differences in sensitivity. Cortical and striatal slices were prelabeled with [3H… CONTINUE READING