Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.

@article{Pelissier2014AgerelatedDI,
  title={Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.},
  author={Fanny A. Pelissier and James E. Garbe and Badriprasad Ananthanarayanan and Masaru Miyano and ChunHan Lin and Tiina Jokela and S. Kiran Kumar and Martha R. Stampfer and James B Lorens and Mark A LaBarge},
  journal={Cell reports},
  year={2014},
  volume={7 6},
  pages={
          1926-39
        }
}
Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus (stiffness). Increased stiffness causes a differentiation bias towards myoepithelial cells while reducing production of luminal cells and progenitor maintenance. Lineage representation in progenitors from women >55… CONTINUE READING
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