Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain

@article{Kaasinen2000AgerelatedDD,
  title={Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain},
  author={V. Kaasinen and H. Vilkman and J. Hietala and K. N{\aa}gren and J. Rinne},
  journal={Neurobiology of Aging},
  year={2000},
  volume={21},
  pages={683-688}
}
Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there are age-associated changes in dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the striatum, a D2/3R selective high-affinity radioligand [11C]FLB 457 was used in positron emission tomography (PET) examinations for 24 normal healthy male subjects (age range 19-74 years). Significant age-related… Expand
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