Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
@article{Kaasinen2000AgerelatedDD, title={Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain}, author={Valtteri Kaasinen and Harry Vilkman and Jarmo Hietala and Kjell N{\aa}gren and Hans Helenius and Hans Olsson and Lars Farde and Juha O. Rinne}, journal={Neurobiology of Aging}, year={2000}, volume={21}, pages={683-688} }
350 Citations
Extrastriatal dopamine D2 receptors in Parkinson's disease: a longitudinal study
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The longitudinal study shows first evidence concerning cortical D2 receptor loss in the progression of PD, although it is not possible to distinguish between the effects of the therapy and the disease.
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The results indicate that the extrastriatal D2‐like receptor availability decreases with age in healthy women with the fastest rate in the frontal cortex and with the overall rate close to the rate reported in healthy men.
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D1 receptor densities in different pathways are not regulated independently in younger adults, but segregate in older age, and that this segregation of D1 receptor systems may be related to age-related cognitive slowing.
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Extrastriatal dopamine D2/3 receptor density and distribution in drug-naive schizophrenic patients
- Psychology, MedicineMolecular Psychiatry
- 2003
The findings indicated an extremely low D2/3 receptor binding among patients in temporal cortex in both hemispheres when compared with controls, which support the previous hypothesis on dysfunction of mesocortical DA function behind the cognitive and negative symptoms in schizophrenia.
Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with l-[β-11C]DOPA
- Biology, Psychology
- 2006
Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
- MedicineSynapse
- 2004
Preliminary evidence is given that DA D2 receptors in cortical areas may be lower among both groups of alcoholics, but not necessarily of same magnitude as in subcortical structures.
Age-related changes in midbrain dopaminergic regulation of the human reward system
- Biology, PsychologyProceedings of the National Academy of Sciences
- 2008
These findings provide an important characterization of the interactions between midbrain dopamine function and the reward system in healthy young humans and older subjects, and identify the changes in this regulatory circuit that accompany aging.
The role of the striatal dopamine transporter in cognitive aging
- PsychologyPsychiatry Research: Neuroimaging
- 2005
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