Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain.

@article{Kaasinen2000AgerelatedDD,
  title={Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain.},
  author={Valtteri Kaasinen and Harry Vilkman and Jarmo Hietala and Kjell N{\aa}gren and Hans Y Helenius and H. I. Olsson and Lars Farde and Juha O. Rinne},
  journal={Neurobiology of aging},
  year={2000},
  volume={21 5},
  pages={683-8}
}
Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there are age-associated changes in dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the striatum, a D2/3R selective high-affinity radioligand [11C]FLB 457 was used in… CONTINUE READING