Age-related diseases as vicious cycles

@article{Belikov2019AgerelatedDA,
  title={Age-related diseases as vicious cycles},
  author={Aleksey V. Belikov},
  journal={Ageing Research Reviews},
  year={2019},
  volume={49},
  pages={11-26}
}
The mortality rates of age-related diseases (ARDs) increase exponentially with age. Processes described by the exponential growth function typically involve a branching chain reaction or, more generally, a positive feedback loop. Here I propose that each ARD is mediated by one or several positive feedback loops (vicious cycles). I then identify critical vicious cycles in five major ARDs: atherosclerosis, hypertension, diabetes, Alzheimer's and Parkinson's. I also propose that the progression of… Expand
19 Citations
Senescent cells and the incidence of age‐related diseases
  • Highly Influenced
Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.
  • 10
...
1
2
...

References

SHOWING 1-10 OF 388 REFERENCES
Aging, Longevity, Inflammation, and Cancer
  • 198
Type 1 diabetes as a relapsing–remitting disease?
  • 215
Free Radical Theory of Aging: An Update
  • D. Harman
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2006
  • 495
Alzheimer’s as a metabolic disease
  • 66
The role of cellular senescence in aging through the prism of Koch-like criteria
  • 21
Geroconversion: irreversible step to cellular senescence
  • 81
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.
  • C. Franceschi, J. Campisi
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2014
  • 1,590
  • PDF
Infection and type 1 diabetes mellitus - a two edged sword?
  • 46
...
1
2
3
4
5
...