Senescent cells and the incidence of age‐related diseases
- MedicineAging cell
A physiological mechanism for the threshold concentration for several disease classes is proposed, including an etiology for diseases of unknown origin such as idiopathic pulmonary fibrosis and osteoarthritis, and can be used to design optimal treatments that remove senescent cells.
Dynamic supraparticles for the treatment of age-related diseases
- BiologyScience Bulletin
Cellular Aging Characteristics and Their Association with Age-Related Disorders
The role and dysregulation of the molecular pathways controlling cell metabolism and proteostasis, the complexity of the mechanisms that occur during aging, and their association with various age-related disorders are emphasized.
Role of the mtDNA Mutations and Mitophagy in Inflammaging
- BiologyInternational journal of molecular sciences
The role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation, are focused on.
Clinical perspectives on the age-related increase of immunosuppressive activity
- Biology, MedicineJournal of molecular medicine
Given that both the aging and chronic inflammatory states involve the activation of immunosuppression and immunosenescence, this might explain why aging is a risk factor for tumorigenesis and chronicinflammatory states and conversely, chronic inflammatory insults promote the premature aging process in humans.
Lipids: biomarkers of healthy aging.
The study of serum, and plasma lipidome in centenarians, and elderly individuals without age-related diseases can be a useful tool for the identification of aging biomarkers, and to understand physiological aging, and longevity.
Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer's Disease
- BiologySSRN Electronic Journal
Beyond demonstrating a role for histone lactylation in a neurodegenerative disease and showing how multi-layered regulatory impacts attend altered glucose metabolism in microglia, this study illustrates that disrupting a positive feedback loop may support the development of innovative AD therapies.
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease.
- BiologyCell metabolism
Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.
- BiologyAmerican journal of respiratory cell and molecular biology
This review outlines the features of lncRNAs reportedly implicated in regulating the airway inflammatory responses to cigarette smoke exposure and their possible association with COPD pathogenesis.
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
- BiologyMechanisms of Ageing and Development
SHOWING 1-10 OF 367 REFERENCES
Aging, Longevity, Inflammation, and Cancer
- BiologyAnnals of the New York Academy of Sciences
It seems reasonable to conclude that centenarians are endowed with a peculiar resistance to cancer, and the opposite effect of IL‐6 and IL‐10 common gene polymorphisms in cancer and longevity is intriguing, which prompts considerations of the role that antagonistic pleiotropy plays in disease and in longevity.
Free Radical Theory of Aging: An Update
- MedicineAnnals of the New York Academy of Sciences
The extensive studies based on the FRTA hold promise thatALE‐B and the MLS can be extended, the ALE‐B possibly by a few years, and theMLS somewhat less.
Alzheimer’s as a metabolic disease
This article appeals to the inverse comorbidity of cancer and AD to show that the amyloid hypothesis, a genetic and neuron-centric model of the origin of sporadic forms of AD, is not consistent with epidemiological data concerning the age-incidence rates of AD.
The role of cellular senescence in aging through the prism of Koch-like criteria
- MedicineAgeing Research Reviews
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
- BiologyNature communications
Modulation of either proteasome activity or autophagic-lysosomal potential extends lifespan and protects organisms from symptoms associated with proteostasis disorders, suggesting that protein clearance mechanisms are directly linked to ageing and age-associated diseases.
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.
- Medicine, BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging.
Geroconversion: irreversible step to cellular senescence
- BiologyCell cycle
Stress–and oncogene-induced accelerated senescence, replicative senescences in vitro and life-long cellular aging in vivo all can be described by 2-step model.
Hypertension and vascular calcification: a vicious cycle?
- BiologyJournal of hypertension
A hypothetical vicious cycle exists between hypertensive arterial damage and vascular calcification, and clinical and basic science findings supporting this possibility are revised.
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
These and other recent findings highlight both causal and potentiating roles for telomere attrition in human diseases, especially in diseases of human aging and in some aging-related processes.
Epigenetics of aging and aging-related disease.
- BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
This short review highlights key epigenetic players in the regulation of aging, as well as both future goals and challenges to the utilization of epigenetic strategies to delay and reverse the main diseases of aging.